曾宪思，副教授，硕士生导师
学 历：博士
专 业：环境生物学
办公室：生物楼418
Email：zxs-2005@vip.163.com
教育经历
2005.09-2009.07 信阳师范学院，学士
2009.09-2014.06 昆明理工大学，博士
工作经历
2014.07-至今 信阳师范学院新葡的京集团8814 讲师、副教授
2017.08-2018.08 圣路易斯华盛顿大学医学院 访问学者
社会兼职
美国神经化学协会会员，Neurotoxicity Research等多个国际SCI期刊的审稿人。
教学情况
先后主讲本科生《生物制药工艺学》、《生物化学》、《药物分析实验》和《专业英语》等课程，研究生《专业英语》课程。
研究领域
帕金森病的发病机制及硫氧还蛋白的神经保护作用。
获资助项目
主持国家自然科学基金青年项目、河南省科技攻关项目、河南省高等学校重点科研项目基础研究项目、河南省高层次人才国际化培养项目和信阳师范学院博士科研启动基金项目。
代表性论文
† co-first author，*Corresponding Author
Xian-Si Zeng†*, Wen-Shuo Geng†, Lei Chen and Jin-Jing Jia*. Thioredoxin as a Therapeutic Target in Cerebral
Ischemia. Current Pharmaceutical Design, 2018, 24 (25): 2986-2992. (IF=2.757，期刊约稿文章)
Xian-Si Zeng, Wen-Shuo Geng and Jin-Jing Jia*. Neurotoxin-Induced Animal Models of Parkinson Disease:
Pathogenic Mechanism and Assessment. ASN Neuro. 2018, 10:1759091418777438. (IF=3.03，美国神经化学协会官方
期刊约稿文章)
Xian-Si Zeng*, Wen-Shuo Geng, Jin-Jing Jia*, Lei Chen and Peng-Peng Zhang. Cellular and Molecular Basis of
Neurodegeneration in Parkinson Disease. Frontiers in Aging Neuroscience, 2018,10: 109.(IF=4.504)
Jin-Jing Jia†, Xian-Si Zeng†*, Xin-Qiang Song, Peng-Peng Zhang and Lei Chen*. Diabetes Mellitus and Alzheimer's
Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models. Frontiers in
Pharmacology, 2017, 8: 834(IF=4.4)
Jin-Jing Jia†, Xian-Si Zeng†*, Kun Li, Li-Fang Ma, Lei Chen, Xin-Qiang Song. The expression of thioredoxin-1 in acute
epinephrine stressed mice. Cell Stress and Chaperones, 2016, 21: 935-941.(IF=3.163)
Xian-Si Zeng, Jin-Jing Jia*, Li-Fang Ma. Gensenoside Rb1 protects rat PC12 cells from oxidative stress-induced
endoplasmic reticulum stress: the involvement of thioredoxin-1, Molecular and Cellular Biochemistry, 2015,
410(1-2): 239-246(.(IF=2.613)
Jin-Jing Jia, Xian-Si Zeng, Jing-Mei Zhong, Jie Bai*. The epinephrine increases tyrosine hydroxylase expression
through upregulating thioredoxin-1 in PC12 cells. Biochimie, 2015, 115: 52-58.(IF=3.123)
Jin-Jing Jia†, Xian-Si Zeng†, Xiao-Shuang Zhou, Ye Li, Jie Bai*. The induction of thioredoxin-1 by epinephrine
withdraws stress via interaction with β-arrestin-1. Cell Cycle, 2014, 13(19): 3121-3131. (IF=5.006)
Wen-Li Chen, Xian-Si Zeng, Fu-Cheng Luo, Tao Lv, Xiao-Shuang Zhou, Jie Bai*. The decreased expression of
thioredoxin-1 in brain of mice with experimental autoimmune myasthenia gravis.Neuromuscular Disorders,
2014, 24(8):726-35. (IF=3.464)
Xian-Si Zeng, Jin-Jing Jia, Yongwon Kwon, Sheng-Dong Wang, Jie Bai*. The role of thioredoxin-1 in suppression of
endoplasmic reticulum stress in Parkinson disease. Free Radical Biology and Medicine, 2014, 67:10-18.
(IF=5.271)
Xian-Si Zeng, Xiao-Shuang Zhou, Fu-Cheng Luo, Jin-Jing Jia, Lei Qi, Zhao-Xiang Yang, Wei Zhang , Jie Bai*.
Comparative analysis on neuroprotective effects of ginsenosides Rg1 and Rb1 extracted from Panax
notoginseng against cerebral ischemia. Canadian Journal of Physiology and Pharmacology, 2014, 92:102-108.
(IF=1.556)
Jin-Jing Jia, Xian-Si Zeng, Ye Li, Sha Ma, Jie Bai*. Ephedrine induced thioredoxin-1 expression through β-adrenergic
receptor/cyclic AMP/protein kinase A/dopamine- and cyclic AMP-regulated phosphoprotein signaling
pathway. Cellular Signalling, 2013, 25: 1194-1201. (IF=4.304)
Fu-Cheng Luo, Lu Zhao, Juan Deng, Min Liang, Xian-Si Zeng, Hua Liu, Jie Bai*. Geranylgeranylacetone protects
against morphine-induced hepatic and renal damage in mice. Molecular Medicine Reports, 2013, 7: 694-700.
(IF=1.17)
获奖情况
2016年 信阳师范学院优秀实习指导教师
2017年 信阳师范学院优秀教师
